Meningococcal Serogroup B Vaccine Immunogenicity in High-Risk Groups: What Are the Implications?

Understanding the Category B Recommendation for Serogroup B Meningococcal Vaccine.

Published recommendations of the Advisory Committee on Immunization Practices (ACIP) of the Centers for Disease Control and Prevention, which carry the approval of the Secretary of Health and Human Services, provide guidance on how licensed vaccines should be used. Professional organizations such as the American Academy of Family Physicians and the American Academy of Pediatrics (AAP) also deve...

Immunogenicity and safety of a heptavalent (diphtheria, tetanus, pertussis, hepatitis B, poliomyelitis, Haemophilus influenzae b, and meningococcal serogroup C) vaccine.

In this open, phase II, randomized study, 480 infants from Germany, France and Canada received the heptavalent vaccine (Hepta group) or hexavalent and monovalent meningococcal serogroup C control vaccines (HexaMenC group) co-administered with a 13valent pneumococcal conjugate vaccine at 2, 4 and 12 months of age. Immunogenicity was measured 1 month after the second primary dose, and before and ...

Immunogenicity and safety of a multicomponent meningococcal serogroup B vaccine and a quadrivalent meningococcal CRM197 conjugate vaccine against serogroups A, C, W-135, and Y in adults who are at increased risk for occupational exposure to meningococcal isolates.

Laboratory staff who work with meningococcal isolates are at increased risk for developing invasive disease relative to the general population. This was the first study of laboratory workers who received both a conjugate vaccine against meningococcal serogroups A, C, W-135, and Y (Men ACWY-CRM, Menveo) and an investigational multicomponent vaccine against serogroup B containing factor H binding...

Effectiveness of meningococcal serogroup C vaccine programmes.

Since the introduction of monovalent meningococcal serogroup C (MenC) glycoconjugate (MCC) vaccines and the implementation of national vaccination programmes, the incidence of MenC disease has declined markedly as a result of effective short-term vaccination and reduction in acquisition of MenC carriage leading to herd protection. Monovalent and quadrivalent conjugate vaccines are commonly used...

Meningococcal serogroup B disease in Turkey